What is Leukine used for?
It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Sargramostim is given to people whose ability to make white blood cells is reduced (for instance, due to chemotherapy or exposure to large amounts of radiation).
How is Leukine administered?
The recommended dose is 250 mcg/m2/day administered intravenously over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. Do not administer LEUKINE until the post marrow infusion ANC is less than 500 cells/mm3.
Is Leukine FDA approved?
On March 29, 2018, the FDA approved use of Leukine (sargramostim) to increase survival in adult and pediatric patients acutely exposed to myelosuppressive doses of radiation (Hematopoietic Syndrome of Acute Radiation Syndrome, or H-ARS). Myelosuppression occurs when radiation damages the bone marrow.
Who manufactures Leukine?
BOSTON, Feb. 1, 2018 /PRNewswire/ — Boston-based cancer company Partner Therapeutics, Inc. (PTx) announced today that it has acquired the global rights to develop, manufacture, and commercialize Leukine (sargramostim) from Sanofi.
What type of drug is Leukine?
Drug type: Leukine is a biologic response modifier. Leukine is classified as a colony stimulating factor.
What kind of drug is Leukine?
What Is Leukine? Leukine (sargramostim) is a protein that stimulates the production of white blood cells used to increase white blood cells and decrease the risk of infection in conditions such as cancer, bone marrow transplant, and pre-chemotherapy blood cell collection.
How long does it take for Leukine to work?
Leukine is injected under the skin, or given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. When injected into a vein, the infusion may take up to 24 hours to complete.
How long does it take for Procrit to take effect?
It usually takes 2 to 6 weeks before the number of red blood cells increases in your body. Individual results with PROCRIT® may vary. There are many different types of side effects that can occur with PROCRIT®.
Is GM CSF a cytokine?
Multiple studies have demonstrated that GM-CSF is also an immune-modulatory cytokine, capable of affecting not only the phenotype of myeloid lineage cells, but also T-cell activation through various myeloid intermediaries.
What is the generic name for Leukine?
Leukine (sargramostim) is a granulocyte-macrophage colony-stimulating factor (GM-CSF). It works like the naturally occurring G-CSF protein in your body to stimulate bone marrow to make neutrophils, a type of white blood cell that helps your body fight infections.
Does Leukine need to be refrigerated?
Store LEUKINE solution and reconstituted lyophilized LEUKINE solutions under refrigeration at 2°C-8°C (36°F-46°F); DO NOT FREEZE.