What is solid dispersion?
The term solid dispersion refers to the dispersion of one or more active ingredients in a hydrophilic inert carrier matrix at molecular level. It is prepared by the melt (fusion) method and solvent evaporation technique. However, the process is individualized depending on the interaction between drug and carrier.
What is solid dispersion Slideshare?
SOLID DISPERSION. Definition: The technology is the science of dispersing one or more active ingredients in an inert matrix in the solid stage. Need of solid dispersion: Increases Oral bioavailability of a drug. Increased dissolution rate.
What are solid dispersions in physical pharmaceutics?
Solid dispersions, defined as the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and an efficient technique to improve dissolution of poorly water-soluble drugs to enhance their bioavailability.
How does spray drying work?
A spray dryer takes a liquid stream and separates the solute or suspension as a solid and the solvent into a vapor. The solid is usually collected in a drum or cyclone. The liquid input stream is sprayed through a nozzle into a hot vapor stream and vaporized. Solids form as moisture quickly leaves the droplets.
Why can spray drying produce an amorphous API?
From amorphous to crystalline products When starting from a product solution, spray drying is known to produce predominately amorphous material due to the almost instantaneous transition between liquid and solid phases.
Why solid dispersion is done?
Solid dispersion is an effective way of improving the dissolution rate of poorly water soluble drugs and hence its bioavailability. The water soluble carriers used in preparation of solid dispersion enhance the dissolution rate of the poorly water soluble drug.
How is solid dispersion prepared?
Solid dispersions are reduced in size by mortar and sieved. Drug is dissolved in suitable solvent and the required amount of carrier is dissolved in water. Solutions are then mixed by sonication or other suitable method to produce a clear solution, which is then spray dried using spray dryer.
What is solid liquid dispersion?
Solid/liquid dispersion is a process for immersing solid particles in a liquid in a homogeneous manner.
Why solid dispersion is important?
What are advantages of the spray drying process?
Benefits of Spray-Drying Some of the advantages of spray-drying include its ability to be fully automated and continuous. Short residence times and suitability for both heat-sensitive and heat-resistant foods are other advantages. The technology is suitable for a variety of feed materials, provided they are pumpable.
What is spray drying process?
Spray drying is a well understood process that is ideally suited for the manufacture of amorphous dispersions. As shown in Figure 2, drug and polymer are dissolved in an organic solvent to form a solution that is atomized into droplets. The droplets are dried upon contact with a hot drying gas inside the spray drying chamber.
What is spray dried dispersion (SDD)?
In cases when the API and excipient are not thermodynamically miscible with one another in the solid state, the spray dried dispersion (SDD) is formulated such that the resulting Tg of the mixture, including absorbed water, is at least 10°C to 20°C greater than typical storage conditions.
What is the concept of solid dispersion?
The concept of solid dispersion was originally proposed by Sekiguchi & obi. Increasing the dissolution, absorption & therapeutic efficacy of drugs in dosage forms. Increasing solubility in water. Improving the oral absorption and bioavailability of BCS Class II drugs.
Why do we need a secondary drying step after spray drying?
A secondary drying step is often needed to remove residual solvent to a safe concentration for human consumption and ensure good physical state stability. It is impractical to dry to such a low-solvent concentration during the spray drying process due to short particle residence times in the spray dryer.