What is rotenone and how is it typically used?
Rotenone (Fig. 50.1A) is a natural compound, used as an insecticide and a herbicide. Rotenone is a naturally occurring complex ketone, derived from the roots of Lonchocarpus species (Uversky, 2004). It is a commonly used pesticide and is also used in lakes and reservoirs to kill fish that are perceived as pests.
Is rotenone toxic to fish?
Any rotenone that escapes downstream is toxic to fish, and the applicator is responsible for any fish mortalities. The amount of rotenone required to treat a pond effectively is determined by the volume of water expressed in acre-feet and the species of fish in the pond.
What is rotenone what is its effect on metabolism?
We conclude that rotenone and antimycin A inhibit the sodium-dependent transport of fluid, phosphate, and glucose by blocking mitochondrial ATP production. Furthermore, the inhibition of mitochondrial oxidative metabolism and the inhibition of net sodium transport are closely correlated.
How does rotenone affect oxygen consumption?
Exposure of intact and excised gill filaments to rotenone induces an inhibition of their oxygen consumption. This effect was more pronounced when the gill filaments were brought into contact with the rotenone in vivo.
Why is rotenone used?
Rotenone is used as a pesticide, insecticide, and as a nonselective piscicide (fish killer). It is commercialized as cubé, tuba, or derris, in single preparation or in synergistic combination with other insecticides. In the United States and Canada, all uses of rotenone except as a piscicide are being phased out.
Why is rotenone toxic?
Poisoning with rotenone is uncommon but is potentially fatal because this agent inhibits the mitochondrial respiratory chain. In vitro cell studies have shown that rotenone-induced toxicity is reduced by the use of N-acetylcysteine, antioxidants and potassium channel openers.
Why is fish killed by rotenone suitable for human consumption?
Mammals and birds that ingest rotenone by drinking treated water or by eating dead fish would simply digest it without any toxic effect. Most warm blooded animals also have effective natural enzymes that would destroy small amounts entering the blood stream.
How does rotenone affect metabolism?
What were the main aims of the rotenone project?
The specific aims of the project were to: • Determine how the Rondegat River ecosystem responds to the removal of alien fishes over a three year period (2012-2015). Assess rates of recovery of the invertebrate community following rotenone treatment.
How does rotenone affect glycolysis?
Rotenone lowered glucose by promoting glycolysis and inhibiting hepatic glucose output in vitro. To explore the hypoglycaemic effect of rotenone, anaerobic respiration indicated by lactate release in HepG2 hepatocytes and C2C12 myotubes was also measured (n = 4–8/group).