What does histone deacetylation do?
Histone deacetylase (HDAC) is an enzyme that removes the acetyl group from histone proteins on DNA, making the DNA less accessible to transcription factors.
What is HDAC1 gene?
Entrez Gene Summary for HDAC1 Gene Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex.
What is the mTOR gene?
The MTOR gene provides instructions for making a protein called mTOR. This protein is found in various cell types throughout the body including brain cells. It interacts with other proteins to form two distinct protein groups, called mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2).
What is Raptor and Rictor?
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol.
Which enzymes acetylation and deacetylation histone side chains?
Histone acetyltransferases (HATs), sometimes referred to as lysine acetyltransferases or KATs, form a superfamily of enzymes that acetylate the side-chain amino group of lysine residues on histones, and in some cases also other proteins.
Does fasting inhibit mTOR?
Because mTOR is a nutrient-sensing pathway, it can be deactivated by fasting and severe calorie restriction (CR), which exert metabolic effect that are somewhat similar, but not identical, to those of rapamycin42.
How do I increase my mTOR?
Both strength training and eating a meal rich in amino acids result in an increase in protein synthesis. The increase in protein synthesis in both cases is dependent on a protein kinase called the mammalian target of rapamycin (mTOR). Strength training and amino acid ingestion (eating) activate mTOR in different ways.
What is Rictor protein?
RICTOR is a subunit of the mammalian target of rapamycin complex 2 (mTORC2) which contains mTOR, GβL, RICTOR (this protein) and mSIN1. The mammalian target of rapamycin (mTOR) is a highly conserved Ser/Thr kinase that regulates cell growth and proliferation.
What causes acetylation and deacetylation?
The mechanism for acetylation and deacetylation takes place on the NH3+ groups of lysine amino acid residues. These residues are located on the tails of histones that make up the nucleosome of packaged dsDNA. The process is aided by factors known as histone acetyltransferases (HATs).