Is IL-17A inflammatory?
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been recently licensed or are in clinical development.
Does Th17 secrete IL-17?
Introduction. In the 1990s, the novel cytokine interleukin-17 (IL-17) was identified and cloned from a CD4+ T-cell library (1), after which a new type of helper T cells, named Th17 cells, was revealed. Although there are six members of the IL-17 family (A–F), only IL-17A and IL-17F are secreted by Th17 cells (2).
Does IL-17 activate macrophages?
These results suggest that long-term treatment with systemic IL-17A also activates macrophages in the skin of B6 mice in a different way from the LPS-induced macrophage activation. Long-term treatment with systemic IL-17A-activated macrophages in the skin of B6 mice.
What does IL-17 do in rheumatoid arthritis?
Effects of interleukin (IL)-17A on isolated cells involved in the synovitis. Rheumatoid synovium is characterized by hyperplasia, neoangiogenesis and excessive inflammation. IL-17A mediates cartilage and bone destruction that occurs in rheumatoid arthritis (RA) mainly through its action on synoviocytes and osteoblasts.
Are Th17 cells Tregs?
The Th17/Treg Balance in Autoimmunity Th17 cells produce IL-17, IL-22, and IL-23, recruit neutrophils, and promote inflammation at the infection site. By contrast, Treg cells produce anti-inflammatory cytokines IL-10 and TGF-β, suppress activity of a variety of immune cells, and thereby inhibit immune responses.
Do macrophages produce il17?
Glandular and peri-glandular CD68+ macrophages and neutrophils were the predominant IL-17 producing cells in PIA lesions. The accumulation of IL-17 expressing cells in PIA lesions presents direct evidence of an inflammatory microenvironment that may support the development of prostate cancer.
What is the difference between IL-17A and IL-17F?
Despite the large number of double- positive cells in these models, IL-17F is dispensable for autoimmune tissue inflammation whereas IL-17A-deficient mice show reduced disease (Ishigame et al., 2009).