What is the difference between Guillain Barre and transverse myelitis?
Guillain-Barre syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy of the peripheral nervous system which comprises of several subtypes, while acute transverse myelitis (ATM) is an immune-mediated disorder of the central nervous system (CNS) [1-2].
What can mimic transverse myelitis?
The initial magnetic resonance imaging (MRI) is usually normal and can mimic the presentation of the acute transverse myelitis (ATM), acute inflammatory demyelinating polyneuropathy, and compressive myelopathies from neoplasm, epidural or subdural hematoma, or abscess.
What is Guillain-Barré syndrome similar to?
Other neurological conditions, which commonly mimic these GBS variants include: brainstem stroke, myasthenia gravis, botulism, infective or inflammatory rhombencephalitis and bacterial, carcinomatous or lymphomatous meningitis.
Is transverse myelitis GBS?
Guillain–Barré syndrome (GBS) and transverse myelitis (TM) both represent immunologically mediated polyneuropathies of major clinical importance. Both are thought to have a genetic predisposition, but as of yet no specific genetic risk loci have been clearly defined.
Is transverse myelitis autoimmune?
Transverse myelitis associated with an autoimmune disorder may be a warning sign of neuromyelitis optica. Neuromyelitis optica occurs more frequently in people with other autoimmune diseases. Vaccinations for infectious diseases have occasionally been associated as a possible trigger.
Is myelitis transverse or MS?
Transverse myelitis is often a onetime illness. But for some people, transverse myelitis is an early symptom of another serious immune disease of the nervous system. One such disease is multiple sclerosis (MS). MS is a chronic (long-term) disease with no cure.
Is transverse myelitis similar to MS?
Though they both damage the myelin sheath that covers nerve-cell fibers, transverse myelitis and multiple sclerosis are noticeably different. Transverse myelitis is caused by inflammation across both sides of spinal-cord segments.
Can low B12 cause transverse myelitis?
Myelopathy due to vitamin B12 deficiency presenting as transverse myelitis. Vitamin B12 deficiency may induce neuropathy, myelopathy, dementia and optic neuropathy. The diagnosis is established by vitamin B12, homocysteine and methylmalonic acid measurements.
Will an MRI show transverse myelitis?
Tests that can indicate a diagnosis of transverse myelitis and rule out or evaluate underlying causes include: Magnetic resonance imaging(MRI) produces a cross-sectional view or three-dimensional image of tissues, including the brain and spinal cord.
Does GBS show up in blood work?
Guillain-Barré syndrome (GBS) is generally diagnosed on clinical grounds. Basic laboratory studies, such as complete blood counts (CBCs) and metabolic panels, are normal and of limited value in the workup. They are often ordered, however, to exclude other diagnoses and to better assess functional status and prognosis.
Can blood test detect Guillain Barre?
It is not uncommon for physicians to order blood tests to help diagnose Guillain-Barré syndrome. In some cases, this can help find the antibody responsible. For example, the Miller-Fisher variant3 of Guillain-Barré is usually associated with an antibody called GQ1b.