What does HCC surveillance mean?
HCC surveillance aims to detect disease at an early stage in order to augment the likelihood of curative treatment. According to AASLD recommendations, patients who have cirrhosis and those who do not have cirrhosis but are at high risk for HCC should be screened.
Who HCC criteria?
LI-RADS Criteria for CT and MRI
| Diagnostic Category | CT/MRI Criteria |
|---|---|
| 74% HCC | No APHE AND: <20 mm with ≥2 additional major features OR ≥20 mm with ≥1 additional major feature |
| 80% malignancy |
How is hepatocellular carcinoma diagnosed?
Tests and procedures used to diagnose hepatocellular carcinoma include:
- Blood tests to measure liver function.
- Imaging tests, such as CT and MRI.
- Liver biopsy, in some cases, to remove a sample of liver tissue for laboratory testing.
Who should be screened for HCC?
From North America. The American Association for the Study of Liver Diseases (AASLD-2017): routine screening is recommended for HCC in adults with cirrhosis. The initial screening is performed with ultrasound (US) with or without alpha- fetoprotein (AFP) every 6 months.
What is the recommendation for hepatocellular carcinoma surveillance in this woman?
How should HCC surveillance be performed? We recommend a combination of liver ultrasound and serum alpha fetoprotein (AFP). Liver ultrasound is recommended as the primary surveillance modality for HCC; it has a modest sensitivity of approximately 60% and a higher specificity of approximately 85–90% [Singal et al.
Who should be screened for hepatocellular carcinoma?
The American Association for the Study of Liver Diseases (AASLD-2017): routine screening is recommended for HCC in adults with cirrhosis. The initial screening is performed with ultrasound (US) with or without alpha- fetoprotein (AFP) every 6 months.
Can you diagnose HCC without biopsy?
If the nodule is larger than 2 cm at initial diagnosis and has the typical features of HCC on one dynamic imaging technique, biopsy is not necessary for the diagnosis of HCC. Alternatively, if the AFP is >200 ng/mL, biopsy is also not required.
When should you suspect HCC?
AFP >400–500 ng/ml is considered diagnostic for HCC, although fewer than half of patients may generate levels that high 39. With values of that magnitude, the specificity of AFP is close to 100% but at a cost to the sensitivity which falls below 45% 40.
Can HCC BE diagnosis without biopsy?
Approach Considerations. The diagnosis of hepatocellular carcinoma (HCC) can often be established on the basis of noninvasive imaging, without biopsy confirmation. Even when biopsy is needed, imaging is usually required for guidance.
What is B7 in HCC?
B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence. Cancer Immunol Immunother.