What is the chemical structure of halothane?
(R)-halothane
| PubChem CID | 445258 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | C2HBrClF3 |
| Synonyms | (R)-halothane (2R)-2-bromo-2-chloro-1,1,1-trifluoroethane Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-, (R)- 51230-17-2 r-halothane More… |
| Molecular Weight | 197.38 |
What are the properties of halothane?
Halothane is a clear colorless highly volatile liquid with a sweet chloroform-like odor . Density 1.875 g / cm3. Boiling point 122.4°F (50.2°C). Noncombustible.
What is the chemical formula of anesthesia?
Isoflurane | C3H2ClF5O – PubChem.
What is the presentation of halothane?
Physical findings in type II halothane hepatotoxicity include delayed pyrexia (up to 75% of patients). Jaundice can be present 7-10 days after exposure, but it may occur earlier in previously exposed patients. Liver tenderness is common but hepatomegaly is usually mild. A nonspecific rash may be observed.
What is halothane hepatitis?
Type II hepatotoxicity (also called halothane hepatitis) is associated with massive centrilobular liver necrosis that leads to fulminant liver failure; the fatality rate is 50%. Clinically, it is characterized clinically by fever, jaundice, and grossly elevated serum transaminase levels.
What is the chemical name of chloroquine?
Chloroquine is a medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects….Chloroquine.
| Clinical data | |
|---|---|
| Identifiers | |
| IUPAC name (RS)-N’-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4-diamine | |
| CAS Number | 54-05-7 |
| PubChem CID | 2719 |
What are halothane two uses?
Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability.
How many atoms are there in halothane?
There are two carbon atoms, one hydrogen atom, one bromine atom, one chlorine atom, and three fluorine atoms in one formula unit of halothane.
What is the formula for calculating anesthesia payments?
Payment for services that meet the definition of ‘personally performed’ is based on base units (as defined by CMS) and time in increments of 15-minute units. Time units are computed by dividing the reported anesthesia time by 15 minutes (17 minutes / 15 minutes = 1.13 units).
How is halothane metabolized?
Halothane is metabolized extensively in hepatocytes by CYP 2E1 and, to a lesser extent, via CYP 2A6 to form trifluoroacetyl chloride, which is chemically reactive and forms trifluoroacetyl adducts with proteins.
How do you administer halothane?
Fluothane (halothane) may be administered by the nonrebreathing technique, partial rebreathing, or closed technique. The induction dose varies from patient to patient but is usually within the range of 0.5% to 3%. The maintenance dose varies from 0.5% to 1.5%.
Is halothane a nonflammable alkene?
Halothane is a nonflammable halogenated alkene with a blood/gas coefficient of 2.3, a MAC of 0.74 in 100% oxygen and 0.29 in 70% nitrous oxide, and a blood/gas coefficient of 2.3. The hypnotic action of halothane is better, but it lacks analgesic effects.
What is the mechanism of action of halothane?
More… Halothane is a nonflammable, halogenated, hydrocarbon and general inhalation anesthetic. Although the exact mechanism of action is unknown, halothane provides relatively rapid induction of anesthesia by depressing the central nervous system, thereby producing a reversible loss of consciousness and sensation. (NCI05)
Is halothane toxic to the liver?
More… Halothane is a potent volatile halogenated anesthetic gas that has been linked to many cases of idiosyncratic acute liver injury that are frequently severe.
What are the disadvantages of halothane?
Slightly water soluble. HALOTHANE is sensitive to exposure to light. Incompatible with oxidizing materials. Tarnishes or corrodes most metals, with the exception of chromium, nickel and titanium. When moisture is present, it attacks aluminum, brass and lead, but not copper. Contact causes rubber and some plastics to deteriorate rapidly. (NTP, 1992)