What is an add-back therapy?
Add-back therapy allows the treatment of women with relapse of endometriosis-associated pain for a longer period, with reduced bone mineral density loss, good control of pain symptoms, and better patient quality of life compared with GnRH analogue alone or oral contraceptive.
What is an add-back of estrogen?
Add-back hormone replacement therapy (HRT) can alleviate the undesirable hypo-oestrogenic effects of the gonadotrophin-releasing hormone (GnRH) agonists, including loss in bone mineral content.
What does a GnRH analogue do when given to a woman?
HRT is given with GnRH analogues to help reduce the bone-thinning effects of the injections. It is especially important if treatment continues beyond 6 months. HRT can also help to reduce other side effects associated with these injections, such as hot flushes, sleep disturbance and mood swings.
How does Lupron help endometriosis?
LUPRON DEPOT suppresses the hormones that cause endometrial tissue to grow. LUPRON DEPOT therapy suppresses the signals from the pituitary gland in the brain to the ovaries, which stimulate estrogen production. By doing this, LUPRON DEPOT injections also suppress the hormones that cause endometriosis to grow.
Do you need add-back therapy with Orilissa?
The results showed that Orilissa effectively and rapidly reduced heavy menstrual bleeding, with and without add-back therapy, compared with placebo.
How does GnRH agonist work in endometriosis?
GnRH analogue can refer to either agonist or antagonist medications. GnRH agonists work by down-regulating the hypothalamic-pituitary-gonadal axis, ultimately leading to suppression of ovulation and reduced estrogen levels, a key hormone known to stimulate endometriosis (2,3).
How do you increase GnRH naturally?
Plants and plant derivatives that affect fertility disorders and mainly increase GnRH, include Vitex agnus-castus, Thuja occidentalis L., Cimicifuga racemosa, Yucca schidigera, isoflavones and some Chinese herbal compounds.
Does GnRH cause weight gain?
Suppressing sex hormone levels in premenopausal women with gonadotropin-releasing hormone (GnRH) agonist therapy also causes fat gain. For example, women treated for 16 weeks with a GnRH agonist gained 1.0 kg of fat, which equates to an energy excess of about 80 kcal per day.
What is add back therapy Lupron?
Use of norethindrone acetate in combination with LUPRON DEPOT 3.75 mg or 11.25 mg is referred to as add-back therapy and is intended to reduce the loss of bone mineral density (BMD) and reduce vasomotor symptoms associated with use of LUPRON DEPOT 3.75 mg or 11.25 mg.
How long does it take GnRH to work?
You should notice an improvement in your symptoms within 4–8 weeks of beginning treatment, but some women will experience a temporary worsening of symptoms in the first 2 weeks.
What does Zoladex do for endometriosis?
In endometriosis, this medicine is used to reduce endometrial lesions and to thin the endometrium (lining of the uterus) before surgery to remove endometriotic tissue growing outside the uterus. Zoladex is an implant injected every month under the skin.