Can statins cause elevated CK levels?
Statins can magnify exercise-induced marked elevation of the CK.
When should I stop taking statins with elevated CK?
In summary routine monitoring of CK is not recommended for patients receiving statin therapy. Patients with unexplained symptoms of weakness, muscle aches and soreness should have statin therapy stopped and prompt laboratory evaluation of CK.
Can atorvastatin cause elevated CK?
The most commonly reported adverse effect of statins is myopathies and myalgias. Statins may increase serum concentrations of creatine kinase (CK), which is often found in patients experiencing this adverse effect.
When do you check CK with statins?
According to current guidelines, CK should be checked if muscle symptoms appear. If CK is less than 5 times the upper limit of normal, continue statins and monitor CK.
Can statins cause high muscle enzymes?
A rare but worrisome side effect of taking a cholesterol-lowering statin is the breakdown of muscle tissue. To guard against it, people who take statins have often been advised to have regular blood tests to spot rising levels of creatine kinase (CK), a byproduct of muscle breakdown.
What can cause CK to be elevated?
Increased CK may be seen with, for example:
- Recent crush and compression muscle injuries, trauma, burns, and electrocution.
- Inherited myopathies, such as muscular dystrophy.
- Hormonal (endocrine) disorders, such as thyroid disorders, Addison disease or Cushing disease.
- Strenuous exercise.
- Prolonged surgeries.
- Seizures.
What medicines raise CK levels?
Some medications can also increase CPK. Among them are amphotericin B, ampicillin, some anesthetics, blood thinners, aspirin, clofibrate, dexamethasone, furosemide, alcohol, and cocaine. HIV medications like Isentress and Selzentry have also been reported to increase CPK in some patients.
What labs should be monitored with statins?
This statin panel includes the following tests:
- Lipid Panel (Cholesterol Testing)
- Alanine Aminotransferase (ALT/SGPT)
- Coenzyme Q10 (CoQ10)
- C-Reactive Protein (CRP), High Sensitivity (Cardiac Risk Assessment)
What medicines cause high CK levels?
Statins can cause myalgia, muscle weakness, and rhabdomyolysis. Up to 5% of users develop CK elevation, typically 2 to 10 times the upper limit of normal. CK usually drops after stopping statins but may require weeks to months to normalize. Rarely, statin users develop a serious immune-mediated necrotizing myopathy.
What can cause elevated CK level?
CK is a type of protein. The muscle cells in your body need CK to function. Levels of CK can rise after a heart attack, skeletal muscle injury, or strenuous exercise. They can also go up after drinking too much alcohol or from taking certain medicines or supplements.
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