Is probenecid hard on the liver?
Probenecid is a uricosuric agent used for the treatment of gout usually in combination with other agents. Probenecid has been associated with minor serum aminotransferase elevations and very rarely with hypersensitivity reactions which, even more rarely, can be accompanied by acute liver injury.
What is an alternative to probenecid?
Clinical guidelines also recommend allopurinol (Zyloprim) as a first-choice option rather than probenecid to lower uric acid levels. Compared to probenecid, allopurinol (Zyloprim) works better, is safer, and is a lower-cost medication for gout.
What are the side effects of probenecid?
Probenecid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache.
- upset stomach.
- vomiting.
- loss of appetite.
- dizziness.
What type of drug is probenecid?
Probenecid belongs to a class of drugs known as uricosurics. It lowers high levels of uric acid in your body by helping the kidneys to get rid of uric acid. When uric acid levels get too high, crystals can form in the joints, causing gout. Lowering uric acid levels may also help your kidneys.
Who should not take probenecid?
You should not use probenecid if you are allergic to it, or if you have: uric acid kidney stones; a gout attack that has already started; or. a blood cell disorder, such as anemia or low white blood cells.
Is probenecid an anti inflammatory?
Probenecid (Benemid®, Probalan®) is used to manage hyperuricemia and prevent gout attacks. It’s not designed to treat an acute gout attack or its symptoms. It’s not an anti-inflammatory drug or pain reliever.
What is the generic drug for probenecid?
GENERIC NAME: COLCHICINE/PROBENECID – ORAL (COAL-cheh-seen/pro-BEN-uh-sid)
Why can’t Chinese take allopurinol?
Stern noted that genetic epidemiology can play a strong roll in allopurinol hypersensitivity, as the HLA-B*5801 haplotype, which is prevalent in Han Chinese individuals, is a major risk factor.
How is probenecid metabolized?
The drug is extensively metabolised by glucuronide conjugation and by oxidation of the alkyl side chains; oxidation of the aromatic ring does not occur. The half-life of probenecid in plasma (4 to 12 hours) is dose-dependent.
How do I get a probenecid?
Probenecid is a prescription medication in the United States. Because of this, one cannot just buy probenecid online or get probenecid OTC from a pharmacy without first consulting a licensed medical provider to get a prescription so that the probenecid tablets can be dispensed.
Is probenecid good for gout?
Probenecid is used in the treatment of chronic gout or gouty arthritis. These conditions are caused by too much uric acid in the blood. The medicine works by removing the extra uric acid from the body. Probenecid does not cure gout, but after you have been taking it for a few months it will help prevent gout attacks.
Is probenecid safe for kidney?
Probenecid can increase your risk of kidney stones. Probenecid is not safe to take for many people with kidney disease, so talk to your doctor for more information about probenecid.