What is CTX marker?
Biochemical markers of bone metabolism have been used in medicine to evaluate and provide treatment to patients with metabolic bone diseases, such as osteoporosis. Serum cross-linked C-telopeptide of type I collagen (CTX) is a marker of osteoclast activity and is used to assess the level of bone resorption.
What is NTX and CTX?
The NTX test is based on an antibody against the N-terminal of collagen, including the cross-linking region; CTX is based on an antibody to an octapeptide at the C-terminal end.
What is CTX bone density?
Elevated levels of beta-C-terminal telopeptide (CTx) indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget disease, hyperthyroidism, and hyperparathyroidism.
What does a bone marker test show?
Bone markers are blood and urine tests that detect products of bone remodeling to help determine if the rate of bone resorption and/or formation is abnormally increased, suggesting a potential bone disorder.
What is normal range for CTX?
Adults: 1.03 ± 0.41 ng/mL. Children: 8.00 ± 3.37 ng/mL.
What is a good CTX level?
Information on the Serum CTX Test
| CTX Value | Risk for ONJ |
|---|---|
| 300 to600 pg/ml (normal) | none |
| 150 to 299 pg/ml | none to minimal |
| 101 to 149 pg/ml | moderate |
| Less than 100 pg/ml | high |
How do I read NTx results?
Elevated levels of NTX indicate increased bone turnover. Mild to moderate elevation in turnover markers characterize the unbalanced remodeling of osteoporosis while markedly elevated levels (>1.5–2 fold) may indicate the co-existence of alternative bone conditions like osteomalacia.
What is a normal CTX level?
Is CTX a fasting blood test?
The Serum CTX test requires fasting of 8-10 hours in advance of the blood sample being taken. For this reason, morning samples are preferred.
What is high bone turnover?
High bone turnover is associated with more rapid bone loss in postmenopausal women (9) and BTMs have been studied in evaluation of this relationship. Higher BTMs are associated with bone loss from both trabecular and cortical bone at the hip and also relate to greater periosteal expansion in the femoral neck (10).
Is osteopontin linked to bone mineral density in postmenopausal women?
Background: Osteopontin (OPN) has been implicated in bone remodeling by activating the resorption process. We aimed to study the relationship between OPN, bone mineral density (BMD), bone turnover markers, vitamin D, and osteoporotic vertebral fractures in postmenopausal women.
What are biomarkers of bone turnover?
Biomarkers of bone turnover can be measured in blood or urine and are used in selective combinations of formation and resorption markers that express the metabolic activity of osteoblasts or osteoclasts respectively, although in most circumstances the bone remodelling processes are coupled and tend to change in parallel.
What are the new bone marker standards?
Recent recommendations by the Bone Marker Standards Working Group propose to standardise research and include a specific marker of bone resorption (CTX) and bone formation (P1NP) in all future studies. It is hoped that improved research in turn will lead to optimised markers for the clinical management of osteoporosis and other bone diseases.
What are bone markers and why are they important?
Bone markers are cleared through the liver or kidneys and are also influenced by diseases affecting these systems, decreased GFR for example will decrease the urinary excretion of CTX and therefore increase serum levels. They are also affected by any disease states leading to increased periods of bed rest and immobility.