What is MRH disease?
Multicentric reticulohistiocytosis (MRH) is a rare disease in which papulonodular skin lesions containing a proliferation of true histiocytes (macrophages) are associated with arthritis that primarily affects the interphalangeal joints. [1, 2]
What is reticulohistiocytosis?
Reticulohistiocytosis is a rare form of histiocytosis that can affect the skin and other organs. Reticulohistiocytosis has a wide range of severity. It can be a limited disease with a single yellowish-red skin lump through to multiple skin lesions with internal organ involvement. It usually occurs in adults.
What causes multicentric Reticulohistiocytosis?
In the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome.
What is psoriatic arthritis Mutilans?
Arthritis mutilans is a rare, severe, deforming, and destructive form of psoriatic arthritis that primarily affects the small joints in the fingers and toes closest to the nail. This leads to lost function of those joints. It also is frequently associated with lower back and neck pain.
What causes erdheim Chester disease?
Causes. More than half of people with Erdheim-Chester disease have a specific mutation in the BRAF gene. Mutations in other genes are also thought to be involved in this disorder. The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell’s nucleus.
What does arthritis mutilans look like?
You may have arthritis mutilans if you experience the following symptoms: Severe joint pain and swelling in your hands and feet. Bones in your hands and feet fuse and disappear. Skin lesions, which usually appear before arthritis develops.
Is Erdheim-Chester disease curable?
Erdheim-Chester disease is a rare non-Langerhans histiocytosis with multisystem involvement. To date, there is no standard treatment for this disorder, and more than half of the patients succumb within 3 years.
Is Erdheim-Chester disease painful?
People with Erdheim-Chester disease often have bone pain, especially in the lower legs and upper arms, due to an abnormal increase in bone density (osteosclerosis).
What does MRH stand for?
Objectives: Multicentric reticulohistiocytosis (MRH), a rare histiocytic disease that can mimic other rheumatic conditions, may be associated with cancer and other autoimmune disorders.
What is MRKH syndrome?
Collapse Section Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder that occurs in females and mainly affects the reproductive system. This condition causes the vagina and uterus to be underdeveloped or absent, although external genitalia are normal. Affected women usually do not have menstrual periods due to the absent uterus.
What is Rh disease?
Rh disease (also known as rhesus isoimmunization, Rh (D) disease) is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and not only D-antigen.
What is multicentric reticulohistiocytosis (MCR)?
Multicentric reticulohistiocytosis is a systemic disease of unknown cause, characterized by a reactive proliferation of histiocytes in nodules in the skin, mucosa, subcutaneous tissue, synovium, and bone. Low magnification of multicentric reticulohistiocytosis (MCR) shows a nodular proliferation of enlarged histiocytic cells in the dermis.