What is the purpose of glutamine synthetase?
Glutamine synthetase (GS) plays a critical role in the brain to detoxify ammonia and regulate concentration and compartmentalization of neurotransmitter pools of glutamate and gamma-aminobutyric acid (GABA).
What is Plastidic glutamine synthetase?
The plastidic glutamine synthetase isoform (GS2) plays a key role in nitrogen (N) assimilation. We introduced TaGS2‐2Abpro::TaGS2‐2Ab, the favourable allele of TaGS2‐2A in the winter wheat (Triticum aestivum) variety Ji5265.
What is glutamine synthetase activated by?
Glutamine synthetase uses ammonia produced by nitrate reduction, amino acid degradation, and photorespiration. The amide group of glutamate is a nitrogen source for the synthesis of glutamine pathway metabolites….Glutamine synthetase.
| glutamate—ammonia ligase | |
|---|---|
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
Is glutamine synthetase A protein?
A Molecular Computer The enzyme glutamine synthetase is a key enzyme controlling the use of nitrogen inside cells. Glutamine, as well as being used to build proteins, delivers nitrogen atoms to enzymes that build nitrogen-rich molecules, such as DNA bases and amino acids.
Which cells express glutamine synthetase?
Neurones express glutamine synthetase when deprived of glutamine or interaction with astrocytes. J Neurochem. 2010 Sep 1;114(5):1527-36.
How is glutamine synthetase regulated?
Detailed studies of the glutamine synthetase (GS) in Escherichia coli and other bacteria have shown that the activity of this enzyme is regulated by at least five different mechanisms: (i) cumulative feedback inhibition by multiple end products of glutamine metabolism, (ii) interconversion between taut and relaxed …
Is glutamine synthetase reversible?
Glutamine synthetase (GS) is the central enzyme for nitrogen assimilation in Escherichia coli and is subject to reversible adenylylation (inactivation) by a bifunctional GS adenylyltransferase/adenylyl-removing enzyme (ATase).
Is glutamine synthetase ubiquitous?
Glutamine synthetase (GS, E.C. 6.3. 1.2) is a ubiquitous and highly compartmentalized enzyme that is critically involved in several metabolic pathways in the brain, including the glutamine-glutamate-GABA cycle and detoxification of ammonia.