Which is better amikacin or gentamicin?
The results indicate that amikacin is effective against severe gram-negative infections and is not more and not less ototoxic or nephrotoxic than gentamicin.
Is amikacin and gentamicin difference?
Amikacin is more stable than gentamicin to enzyme inactivation. Amikacin is used in the treatment of serious infections caused by gentamicin-resistant Gram-negative bacilli. Tobramycin has similar activity to gentamicin. It is slightly more active against Ps.
Which is more toxic gentamicin or amikacin?
In conclusion, in pts with initial normal renal function gentamicin was significantly more nephrotoxic than amikacin.
What antibiotic is similar to gentamicin?
Cephalexin.
What is gentamicin used for?
Descriptions. Gentamicin injection is used to treat serious bacterial infections in many different parts of the body. Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth.
Can amikacin be given once daily?
For elderly patients a smaller dose of amikacin than the regular daily dose of 15 mg/kg bw, i.e. about 11 mg/kg bw, seems recommendable, when it is given once daily. From the data obtained it is also obvious that once-daily dosing of amikacin does not eliminate the need for checking serum concentrations of the drug.
What are two serious side effects of gentamicin and tobramycin?
Let your child’s doctor or nurse know as soon as possible if your child has any of these side effects:
- loss of hearing.
- ringing or buzzing in the ears.
- feeling of fullness of the ears.
- increased thirst.
- needing to urinate more or less frequently than usual.
- skin rash or itchiness.
- unusual drowsiness, dizziness, or weakness.
How effective are amikacin and gentamicin in the treatment of Gram-negative bacteremia?
Abstract. Amikacin or gentamicin was used to treat 174 patients with suspected severe gram-negative infections in a prospective, randomized, double-blind trial. Enteric gram-negative bacilli were pathogenic in 71 cases (39 treated with amikacin, and 32 with gentamicin). Amikacin was effective in 10 of 12 bacteremias,…
How much gentamicin do you give amikacin?
With 2 mg per kilogram of gentamicin or 8 mg per kilogram of amikacin given intravenously every eight hours in patients with normal renal function, effective serum levels were obtained in most patients. In addition, monitoring serum levels frequently resulted in dosage changes during therapy.
What is amikacin used to treat?
Amikacin or gentamicin was used to treat 174 patients with suspected severe gram-negative infections in a prospective, randomized, double-blind trial. Enteric gram-negative bacilli were pathogenic in 71 cases (39 treated with amikacin, and 32 with gentamicin).
Can amikacin be used on Gram negative aerobes?
Drug Resistance. Therefore, a large proportion of the gram-negative aerobes that are resistant to gentamicin and tobramycin are sensitive to amikacin. In addition, with increased use of amikacin, a lower incidence of resistance has been observed compared with increased use of gentamicin and tobramycin.